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Gitox (Losartan)
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Gitox

Gitox is a hypertension treatment. Research suggests that the medication is safe and effective for most people. People may experience mild side effects, such as dizziness, in the early stages of treatment. People who experience severe or persistent side effects should contact their doctor right away.

Other names for this medication:
Cardoplus, Cardzaar, Corodin, Corus, Cozaarex, Czartan, Enromic, Gitox, Hilos, Hizaar, Hypozar, Insaar, Lepitrin, Loben, Logika, Loplac, Losadel, Losamet, Losan, Losap, Losaprex, Losarb, Losartas, Losartax, Losatan, Losazid, Losazide, Lostat, Lotim, Lozatan, Maxartan, Myotan, Niten, Ozarium, Psycholanz, Ranlozar, Rasoltan, Sarilen, Sarlo, Sartens, Satoren, Tanlozid, Tarnasol

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Also known as: Losartan

Description

Gitox (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Gitox is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Gitox is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Gitox 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Gitox 25 mg, Gitox 50 mg, and Gitox 100 mg may also contain carnauba wax.

Dosage

Take Gitox tablets orally with or without food. Do not crush or chew it. Take Gitox once or twice a day at the same time. If you want to achieve most effective results do not stop taking Gitox suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Gitox are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Gitox as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Gitox. Correct volume or salt depletion prior to administration of Gitox.

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Frequency of ST-segment depression produced by mental stress in stable angina pectoris from coronary artery disease. Disseminated intravascular coagulation in association with congenital neuroblastoma. Antibodies to p24 and gp120 were assessed by enzyme-linked immunosorbent assay. All neurographic parameters were obtained by means of simultaneous recording with surface and concentric needle electrodes and compared with one another. This strain may be used as a bacterial preparation for the regulation of intestinal microbiocenosis. Changes in fatty acid compositions of mitochondria during embryonic development. Protecting hospital employees and visitors from aerosolized ribavirin. Animals were repeatedly trained to retrieve food rewards from three arms, until a criterion level of performance was reached. Recently developed methods enable the direct and scalable identification of the signaling pathways capable of driving resistance in specific contexts.

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Determination of cellular DNA content in the diagnosis and prognosis of mesenchymal tumors. Combined single day 14C-triolein breath test and PABA test in the diagnosis of malabsorption. Sensitization to fluorine and manganese compounds and the state of the oral cavity in workers in the electric pipe welding industry. Thallium-201 single photon emission computed tomography in the evaluation of thymic carcinoma. As an adjunct to cancer chemotherapy, we had succeeded in creating the methionine depletion in vivo, using the technique of total parenteral nutrition (TPN) by infusing an amino acid solution devoid of methionine and cysteine, as sole nitrogen source (Met-deplet.

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