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Diamin (Imipramine)

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Diamin works by inhibiting the reuptake of certain neurotransmitters in the brain, including acetylcholine, dopamine, norepinephrine, and serotonin. It also acts on certain other receptors, such as H1 receptors for histamine. Diamin usually is administered orally but may be given by intramuscular injection.

Other names for this medication:
Alzoset, Antidep, Antipres, Anxitab, Depforte, Depik, Depnil, Depof, Depranil, Deprid, Depsan, Depsin, Depsol, Depsolam, Depsonil, Diamin, Diazariv, Elamin, Eldep, Elidep, Endopax, Estidep, Finezol, Imidiaz, Imikon, Imilor, Iminza, Imipam, Imipra, Imipramine, Imodep, Impramine, Impranit, Imprax, Imprim, Imprin, Karthin, Lastinem, Libomin, Microdep, Nimipose, Normadep, Prazep, Talendep, Trydep

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Also known as: Imipramine


Imipramine is used to treat depression. It belongs to a group of medicines known as tricyclic antidepressants (TCA). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain.

Imipramine tablets are also used to treat enuresis (bedwetting) in children.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain imipramine. It may not be specific to Diamin-PM. Please read with care.

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (capsules): For depression: Adults—At first, 75 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day, unless you are in the hospital. Some hospitalized patients may need higher doses. Teenagers and older adults—At first, 25 to 50 mg per day using the tablets. Your doctor may adjust your dose as needed and switch you to the capsule form. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): For depression: Adults—At first, 75 milligrams (mg) per day. Your doctor may adjust your dose as needed. However the dose is usually not more than 200 mg per day. Some hospitalized patients may need higher doses. Teenagers and older adults—30 to 40 mg per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For enuresis (bedwetting): Children 6 years of age and older—At first, 25 milligrams (mg) once a day, taken 1 hour before bedtime. Your doctor may adjust the dose as needed. Children younger than 6 years of age—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Diamin can be fatal.

Overdose symptoms may include irregular heartbeats, feeling like you might pass out, seizures, or coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Diamin-PM dosage information

Side effects

The most common side effects associated with Diamin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Prospective multicentre systematic guideline-based management of patients referred to the Syncope Units of general hospitals. Therefore, the aim of the study was to verify dietary effects of water- or milk replacer-based oral rehydration solutions on parameters of acid-base balance in calves with experimentally induced hyperchloremic and dl-lactate acidosis. Strikingly, Exportin 5 (XPO5) is promptly induced during cell cycle entry by a PI3K-dependent post-transcriptional mechanism. To determine if BMS-387032 was a P-glycoprotein substrate, brain uptake studies were conducted in P-glycoprotein knockout versus wildtype mice. Tricuspid regurgitation is a significant risk factor for reoperation and mortality in patients with hypoplastic left heart syndrome.

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The use of ultrasound for neuraxial blockade is a new application of technology that is rapidly becoming accepted as a standard of care. In higher plants, this pathway involves the trafficking of proteins and various forms of RNA that function non-cell-autonomously to affect developmental programmes. Unfortunately, the current effective vaccines are a live vaccine for chlamydiosis and killed vaccine for Q fever. The goal of improving drug safety is sought by the FDA, patients, health care providers, and health systems alike. Since virus-specific immunofluorescence (FA) is detectable in hamster pancreas during the acute phase of Venezuelan encephalitis (VE), experiments were designed to correlate pathologic and virologic events with metabolic studies in VE-infected hamsters. Development of a differentiation scheme for Hafnia using the H antigen. This study was to investigate the biological function of human LRP16 gene by database-aided bioinformatics analysis.

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The economic effects of screening for obstructive airway disease: an economic analysis of the DIMCA program. Maximal cytokine-mediated induction was not observed in the presence of protein synthesis inhibitor cycloheximide, suggesting additional regulatory factors play an important role. Ascorbate (15 mM) added to soluble lens proteins prior to photoirradiation can prevent some of these changes. A comparison of unicompartmental knee replacement with total knee replacement. In the multiple regression analysis, HOMA-IR was independently associated with troponin T elevation.

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