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Clindamicin

Clindamicin is a strong broad-spectrum antibiotic, typically prescribed for serious infections, such as life-threatening methicillin-resistant Staphylococcus aureus (MRSA) skin infections.

Other names for this medication:
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Also known as: Clindamycin

Description

Clindamicin is a prescription medication used to treat bacterial infections of the lungs, skin, blood, bones, joints, female reproductive system, and internal organs.

Clindamicin belongs to a group of drugs called lincomycin antibiotics. These work by stopping the growth of bacteria.

This medication is available as a vaginal cream, vaginal suppository, oral capsule, and oral liquid.

This medication is also available in injectable forms to be given directly into a vein (IV) or a muscle (IM) by a healthcare professional.

Common side effects of Clindamicin include nausea, vomiting, joint pain, heartburn, pain when swallowing, and white patches in the mouth.

Dosage

This section provides information on the proper use of a number of products that contain clindamycin. It may not be specific to Clindamicin T. Please read with care.

Before applying this medicine, thoroughly wash the affected areas with warm water and soap, rinse well, and pat dry.

When applying the medicine, use enough to cover the affected area lightly. You should apply the medicine to the whole area usually affected by acne, not just to the pimples themselves. This will help keep new pimples from breaking out.

You should avoid washing the acne-affected areas too often. This may dry your skin and make your acne worse. Washing with a mild, bland soap 2 or 3 times a day should be enough, unless you have oily skin. If you have any questions about this, check with your doctor.

Topical clindamycin will not cure your acne. However, to help keep your acne under control, keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. You may have to continue using this medicine every day for months or even longer in some cases. If you stop using this medicine too soon, your symptoms may return. It is important that you do not miss any doses.

For patients using the topical foam form of clindamycin:

After washing or shaving, it is best to wait 30 minutes before applying this medicine. The alcohol in it may irritate freshly washed or shaved skin. This medicine contains alcohol and is flammable. Do not use near heat, near open flame, or while smoking. To apply this medicine: Do not dispense clindamycin topical foam directly onto your hands because the foam will begin to melt on contact with warm skin. Remove the clear cap. Align the black mark with the nozzle of the actuator. Hold the can upright and press firmly to dispense. Dispense amount that will cover the affected area(s) directly into the cap or onto a cool surface. The can may be placed under cold running water if the can seems warm or the foam seems runny. A small amount of topical foam should be picked up with your fingertips and massaged gently into the affected areas until the foam disappears. Unused medicine that was removed from the can should be throw away. Since this medicine contains alcohol, it will sting or burn. In addition, it has an unpleasant taste if it gets on the mouth or lips. Therefore, do not get this medicine in the eyes, nose, or mouth, or on other mucous membranes. Spread the medicine away from these areas when applying. If this medicine does get in the eyes, wash them out immediately, but carefully, with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor. It is important that you do not use this medicine more often than your doctor ordered. It may cause your skin to become too dry or irritated.

For patients using the topical solution form of clindamycin:

After washing or shaving, it is best to wait 30 minutes before applying this medicine. The alcohol in it may irritate freshly washed or shaved skin. This medicine contains alcohol and is flammable. Do not use near heat, near open flame, or while smoking. To apply this medicine: This medicine comes in a bottle with an applicator tip, which may be used to apply the medicine directly to the skin. Use the applicator with a dabbing motion instead of a rolling motion (not like a roll-on deodorant, for example). Tilt the bottle and press the tip firmly against your skin. If needed, you can make the medicine flow faster from the applicator tip by slightly increasing the pressure against the skin. If the medicine flows too fast, use less pressure. If the applicator tip becomes dry, turn the bottle upside down and press the tip several times to moisten it. Since this medicine contains alcohol, it will sting or burn. In addition, it has an unpleasant taste if it gets on the mouth or lips. Therefore, do not get this medicine in the eyes, nose, or mouth, or on other mucous membranes. Spread the medicine away from these areas when applying. If this medicine does get in the eyes, wash them out immediately, but carefully, with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor. It is important that you do not use this medicine more often than your doctor ordered. It may cause your skin to become too dry or irritated.

For patients using the topical suspension form of clindamycin:

Shake well before applying.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (foam): For acne: Adults and children 12 years of age and over—Apply once a day to areas affected by acne. Infants and children up to 12 years of age—Use and dose must be determined by your doctor. For topical dosage forms (gel, solution, and suspension): For acne: Adults and children 12 years of age and over—Apply two times a day to areas affected by acne. Infants and children up to 12 years of age—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms include bloody or watery diarrhea, which may result if you absorb Clindamicin T through your skin by applying too much.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Clindamicin HCl dosage information

Side effects

The most common side effects associated with Clindamicin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Although appropriate studies on the relationship of age to the effects of clindamycin have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have colitis, which may require caution in patients receiving clindamycin.

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High-pressure transducers were compared with a mercury column manometer, and low-pressure transducers were compared with a water column manometer at three pressure levels. (1) Valproic acid is an anticonvulsant agent widely used in the management of various forms of epilepsy, including absence, myoclonic and tonic-clonic seizures. Patients treated with radiotherapy (RT) alone, sequential and concurrent chemo-RT with and without the addition of cetuximab were studied. This is consistent with the contention that it is a high-level, attention-related effect, phenomenologically similar to polarized gamma movement. After a healing period of 12 months, free of functional loading, the implants with surrounding tissues were removed and specimens analyzed in undecalcified sections. Various strategies are developed to improve stress tolerance in plants. This article reviews the descriptive and topographic anatomy of these structures in details. However, it is not known whether other regions of the A subunit contribute to the assembly. The possibility of multi-angulated approaches makes biopsies of hardly accessible anatomic regions feasible. In vivo validation was performed using both an orthotopic and a flank derivative of a previously established ATC xenograft murine model.

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Broadly neutralizing human monoclonal JC polyomavirus VP1-specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy. Posterior fossa venous angiomas with drainage through the brain stem. The isoenzymes of creatine phosphokinase in acute psychotic states. To improve the efficiency of hepatic intra-arterial (h.i.a.) chemotherapy, we selected pirarubicin (THP) because it shows good properties for h.i.a. The number of mitotic cells in the subependymal layer fell slightly from 1 to 3 days postinjection then returned to normal 5 days postinjection. Thoracic aortic cross-clamping causes an increase in proximal aortic and cerebrospinal fluid pressures. Synergism of type I and type II interferons in stimulating the activity of the same DNA enhancer.

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The alpha-1 adrenoceptor antagonist prazosin, which also binds to alpha-2B receptors, reduced the frequency of both pinning and dorsal contacts. In summary, the relaxation of the bioassay tissues during nerve stimulation was indistinguishable from the relaxation induced by NO, whereas relaxations induced by CYSNO, GSNO, SNAP and hydroxylamine showed different pharmacological profiles. Edema fluid accumulates in the stroma but the tunica albuginea and superficial cortical zone are characteristically uninvolved. Here, we link the key aspects of the current clinical development of alisertib to the originating scientific rationale and provide an overview of the alisertib clinical experience to date. MiR-21 and miR-183 can simultaneously target SOCS6 and modulate growth and invasion of hepatocellular carcinoma (HCC) cells. Effects of social and environmental change on institutionalized mentally retarded persons: the relocation syndrome reconsidered. This model should help identify bacterial and host genes that produce attachment-related pathology.

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Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease. Strategies to address relevant issues are discussed, with reference to the increasing proportion of women in medicine and anaesthesia. These effects were mediated by activation of the nicotinic receptors in the adrenal medulla and sympathetic ganglia. In previous experiments, a neural network was used for feature extraction from a set of known signal peptidase I cleavage sites and served as the fitness function in an evolutionary design cycle leading to idealized cleavage site sequences. Feasibility of comparing risk profiles for cervical cancer between participants and nonparticipants in a screening programme. Modelling the wave movement of a multisegment biomechanical system. Conjugation of CP at the carboxyl terminus with palmitic acid resulted in a greater inhibition of T-cell interleukin-2 (IL-2) production in vitro than peptide alone. These studies emphasise the importance of preserving tissue for DNA extraction from infants dying of inborn errors of metabolism, and also show the way in which information from conventional biochemical studies can complement diagnostic tests using DNA. Germination and outgrowth of Schizosaccharomyces pombe spores isolated by a simple batch centrifugation technique. The mechanism of the nonproportional pharmacodynamic response to the corticosteroid dose is unclear.

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However, after analysis of the antigen-specific isotypes of immunoglobulin (Ig) there was no correlation between the production of gamma-IFN and particular Ig isotypes. In such a case, penetrating keratoplasty performed for keratoconus may also carry the risk of recurrence of the granular dystrophy. In both instances, bile outflow from the papilla was confirmed endoscopically and endoscopic retrograde cholangiopancreaticography (ERCP) was performed. A decade of development in postgraduate training for general practice. Our cases are the fourth and fifth cases of spigelian hernia (SH) in patients under 2 years of age. The transient expression of desmoglein in L-cell lines expressing plakoglobin mRNA resulted in the formation of a complex between plakoglobin and desmoglein and in the accumulation of plakoglobin protein. In the summer of 2014, before the first case of imported Ebola occurred in the USA, the US FDA announced it would issue Emergency Use Authorizations for Ebola virus in vitro diagnostics to speed their availability. The interviews took place between November 7, 1992 and February 8, 1993.

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Studies on the venomous spicules and spines of some moth caterpillars in Japan. The corresponding hydroxylamines and/or amines were identified as reaction products by HPLC and/or GC-MS. A case of metabolic encephalopathy caused by vitamin B 12-dependent methylmalonicaciduria. The electrolytic stents were composed of 3 different layers (iron, isolating polyethylene and tantalum) and were implanted surgically in the bile duct of 8 healthy pigs. Sex differences in the pituitary gonadotropic function in Gobius melanostomus Pallas. Heterotrimeric G proteins, initially believed to be exclusively present in the plasma membrane, have also been found to be associated with intracellular membrane compartments.

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We report experiments on the sympatho-excitatory bulbospinal pathway from the rostral ventral medulla. Although the therapeutic promise of this strategy for tissue regeneration and repair is exciting, important efficacy and safety concerns will need to be addressed before it becomes a reality in the clinical practice. Thiopental was dissolved in saline and injected into embryonating chicken eggs at doses ranging from 0.2 to 4.0 mg per egg. Thrombin, which stimulates tissue plasminogen activator release, did not enhance TC II release, and neither did endotoxin or mellitin. Class VII cells had sharply tapered apical and basilar dendrites, both flat-vesicle and round-vesicle terminals on the somas (14/100 micron2), and no geniculate input. The CCQ appears promising as a screening tool to detect rheumatic disorder in Spanish and Portuguese speaking communities in a developing country. An isolated case of a 4 1/2-month-old infant with typical bitemporal markings and otherwise normal facies is described. These fatty acids also reversed the inhibitory effect of interleukin-6 on prealbumin production. Michael reactions of ascorbic acid, 4th communication: nitrostyrene as a Michael acceptor toward vitamin C. In this report, we compare the mode and tempo of evolution of noncoding sequences of a large intron within Zfy (783 bp) and Zfx (854 bp), homologous genes located on the felid Y and X chromosomes, respectively.

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The possible significance of CMGP in synovial fluid in human osteoarthritis is discussed. Nystedt and co-workers cloned in 1994 a second protease activatable receptor (PAR-2) that could be activated by trypsin but not by thrombin (1). The effect of guar gum on the viscosity of the gastrointestinal contents and on glucose uptake from the perfused jejunum in the rat. Growth inhibition of DU-145 prostate cancer cells by a Bcl-2 antisense oligonucleotide is enhanced by N-(2-hydroxyphenyl)all-trans retinamide. The authors reviewed current literature, research indications, and nursing implications for amnioinfusion. The excretion of that acid is known to be dependent on the intensity of the paraesthesias, the duration of the ailment and the character of concurrent visceral diseases. Clinico-electromyographic studies in compression and reflex syndromes of spinal osteochondrosis.

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When target and inducer had equal contrast polarity, low thresholds of target lines were observed for low inducer contrasts and increased with increasing inducer contrast. We have previously reported activator sequences within nucleotides -83 to -34 in PSG12. Murine mast cells (MC) responded strongly to Hymenolepis microstoma infection. Appendicitis is an important diagnosis in children with cancer, and laparoscopic appendectomy is safe and the procedure of choice. The optimization of group size for fattening rabbits in group housing on grids made of artificial material. The spindle cell proliferation in these tissues may mimic a spindle cell neoplasm and pose a diagnostic problem if an infectious aetiology is not suspected.

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Cytochrome P-450-catalyzed dehydrogenation of 1,4-dihydropyridines. Serum and semen from 90 anti-HCV-positive drug users were tested (27 infected with HIV) for HCV and HGV/GBV-C RNAs by polymerase chain reaction (PCR) assay, hybridization, and sequence analysis. Finally, in patients who fail to respond promptly to percutaneous catheter drainage of a liver abscess, a continuing source of infection, such as perforation of a jejunal diverticulum, should be suspected. The action of salicylic acid on P phenolsulphotransferase, by preventing the excessive activation of carcinogens, is a possible additional pathway by which aspirin can reduce cancer risk. Upon induction of NSEHip2-28 differentiation, at a time when glial fibrillary acidic protein expression became detectable, the expression of all four Id family members initially increased dramatically, and subsequently decreased. In both groups, however, there was a significant increase in elongation at failure noted in the test specimens.

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Under these circumstances, global cerebral glucose extraction was found to be closest to normal during profound optimized hyperventilation, with PaCO2 levels below 25 mm Hg. Scanning laser photostimulation offers many advantages over current techniques: spatial resolution is superb, fibers of passage are not activated, and thousands of presynaptic locations can be stimulated. Hydrolysis is provided by MFPases of the intestinal mucosa and of the liver. Their structures were determined chemically and spectroscopically to be baohuoside VI, tricin, icaritin, icariside I and baohuoside I. Metabolism of 2-acetamido-4-(chloromethyl)thiazole in germfree and conventional rats. Resting haematocrit was reduced, and atrial natriuretic peptide increased in transplant recipients, suggesting increased plasma volume. We can thus systematically study the photon energy dependence of DNA damage formation in these energy regions. Balloon dilatation and biliary stenting serve to open the bile duct strictures. In order to determine the relationship between delay before immobilization and the development of non-union or delayed union, 285 fractures of the scaphoid have been analysed from records and radiographs.

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These results suggest that the reduction of the contents of SPG, i-active, and I-active ganglioside on the erythrocytes was related to the T. Functional diarrheas are not, in most cases, minor clinical forms of lymphocytic or collagenous colitis. Group 4 consisted of nine infants older than 1 month of age with confirmed bronchopulmonary dysplasia. A lentiviral vector encoding HO-1 was constructed, ADSCs were infected with this, and HO-1 protein expression was examined by western blotting. The authors discuss the basic process on which the principle of fluoridation in based--i.e.

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Acute ethanol administration decreased beta-endorphin level in hypothalamus and anterior lobe of pituitary as well as alpha-neoendorphin in the spinal cord. These data indicate that sensory input from the mystacial vibrissae in the adult rat is processed in brainstem, thalamic, and cortical pathways which are predominantly parallel to those which process information from the neighboring common fur sensory receptors.(ABSTRACT TRUNCATED AT 400 WORDS). Long-term nasal mucosal tissue expansion use in repair of large nasoseptal perforations. Hundreds died and thousands were poisoned by rapeseed oil adulterated with aniline and sold illegally in Spain in 1981. The strip was introduced into the isometric area of the original ACL attachment through a drill hole made in the lateral femoral condyle. To determine if Duplex ultrasound (DUS) 1 day after percutaneous transluminal angioplasty (PTA) is prognostic for haemodynamic and clinical results at 1 year. Control patients did not improve significantly or show any trend to do so. Naltrexone in functional hypothalamic amenorrhea and in the normal luteal phase. Influence of renal failure on ciprofloxacin pharmacokinetics in rats. Nucleotide sequence analysis of mRNA from the H-2K locus of the CBA.M523 mouse risperdal injection cost , which has the class I murine MHC mutation H-2Kkml, has established the only alteration to be at the codon for amino acid position 152 as compared to the sequence of standard Kk from both the AKR and CBA inbred mouse lines.

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These results replicate earlier work with speech materials and suggest that temporal delays for both speech and nonspeech auditory materials are processed in the right hemisphere. Two cDNA clones were isolated and found to contain stop codons and frameshifts within the homeodomains. Single CA3 hippocampal pyramidal cells receive excitatory inputs from associational-commissural fibers and from the mossy fibers of dentate granule cells and both pathways exhibit LTP. The first results of whole genome sequences of super-centenarians were received. Without the use of highly effective dentinal adhesives, the cervical margins of tooth-colored adhesive inlays localized in dentin are poorly adapted. Dexamethasone therapy and endogenous cortisol production in severe pediatric head injury. General and rapid methods were developed for determining the extent of non-covalent binding between small molecules and proteins, using the model system of human cytomegalovirus protease minipress medication class and several drug candidates which inhibit the protease by non-covalently binding to it. The effects of stress on lipoproteins and catecholamines in rats. Morphological findings and preliminary considerations on 8 cases of placentitis during rubella. The response then reached a maximum between 14 and 18 gd and subsequently decreased, although it remained significantly present during the first postnatal week.

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Radiographs of the elbow joints revealed complete destruction of the joint surfaces with dislocation of the radius and the ulna, compatible with severe osteolytic arthritis. Hepatic hematopoiesis is dependent on colonization of the organ by extrinsically derived stem cells which, in mammals, are thought to originate only in the yolk sac. A negative study virtually excludes cortical/periosteal or bone marrow invasion. Multicomponent separations proved that the uremic state shows significant differences from the normal state, especially with regard to anionic low-molecular-weight substances. An equal number of self- and experimenter-administered 30-item questionnaires was given to 203 patients with restrictive and obstructive pulmonary diseases. A reduction of graft survival from 5 to 4 days was achieved with a cell number of 10(6) cells, and no immunogenic effect (with the exception of mesangial cells contaminated by a small number of macrophages) was observed in smaller cell numbers. A frequent hMSH2 mutation in hereditary non-polyposis colon cancer syndrome. However, a significant decrease in both membrane-bound enzymatic activities was evidenced in the synaptosomal fraction of older rats. Splenectomy in children with the Norrbottnian type of Gaucher disease is followed by increased blood levels of glucosylceramide and impaired neurological and mental status.

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The patient did not present any neurological sequelae and follow-up MRI did not reveal any signs of vascular or neurological complications. Immunological changes correlated with subclinical deficiencies of iron and zinc, and therapy with these micronutrients for 4 weeks resulted in improvement in immunological responses. Ebbinghaus illusion: context, contour, and age influence the judged size of a circle amidst circles. Problems connected with pathology and the clinico-therapeutic approach are dealt with. Investigations on the pathomorphological changes occurring in the organisms of 4 sheep poisoned experimentally by varying Thiazole-80 doses applied orally were made. Urodynamic outcome of parasacral transcutaneous electrical neural stimulation for overactive bladder in children. Their application to glaucoma is discussed, with particular reference to the pattern electroretinogram. EBV can infect smooth-muscle cells, at least in patients with AIDS, and it may contribute to the pathogenesis of leiomyomas and leiomyosarcomas in children with AIDS. Neurosecretory cells have been observed in the brain, suboesophageal ganglion and all the ganglia of the ventral nerve cord of three aquatic beetles - Hydrus indicus, Cybister limbatus and Sandrocottus dejeani. During period A, no significant difference in blood calcium, phosphorus and magnesium, not in phosphaturia, rate of phosphorus reabsorption (RPR) and ratio maximum RPR/creatinine clearance was found between the two groups.

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Our results indicate a relationship between heat production and amounts of glucose and lactate in the medium. At higher doses (250 micrograms/ml), a complete inhibition of neutrophil migration was observed. Often the extent of the lesion is difficult to define and development of a pulp exposure is an ever present risk. Cross-linkers aid in improving biostability of collagen via different mechanisms. We found that NGF is a wide survival factor for subpopulations of both cutaneous and muscle afferents, whereas the survival effects of BDNF and NT-3 are restricted primarily to muscle afferents. In each centre, specifically trained neurologist interviewed and confirmed the diagnosis according to the ICHD-II criteria. Vesical neck reconstruction in patients with epispadias-exstrophy.

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